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Oliver Fiehn is an analytical chemist. He received his MSc degree in Analytical Sciences in 1993 from Free University Berlin and received his PhD in 1997 at Technical University of Berlin in Analytical Chemistry, having performed graduate research with the Max-Planck Institute for Molecular Plant Physiology in Potsdam.
He is a Professor and Director of West Coast Metabolomics Center (WCMC) at the University of California, Davis. The WCMC is a major aspect of the work in the NIH Metabolomics Consortium whose goal is to develop processes and resources that accelerate and improve the accuracy of the compound identification workflow for experts and medical professionals.
The effects of two different mitochondrial-targeted drugs, SS-31 and NMN, were tested on Old mouse hearts. After treatment with the drugs, individually or Combined, heart function was examined by echocardiography. SS-31 partially reversed an age-related decline in diastolic function while NMN fully reversed an age-related deficiency in systolic function at a higher workload. Metabolomic analysis revealed that both NMN and the Combined treatment increased nicotinamide and 1-methylnicotinamide levels, indicating greater NAD+ turnover, but only the Combined treatment resulted in significantly greater steady state NAD(H) levels.
In dairy cows, early lactation is associated with an energy deficit that is counteracted by increasing the amounts of grains in the diet. Yet, such diet often increases the odds for cows to develop digestive and systemic metabolic derailments, which can likely be detected as undesirable shifts in the serum metabolome. The present study aimed to identify the metabolic signatures of the serum metabolome of early lactation dairy cows fed high-grain diet.